Dr. Bray Links

Saturday, August 4, 2018

The classic EDCs, phthalate esters and organochlorines, in relation to abnormal sperm quality: a systematic review with meta-analysis

Nonetheless, our systematic review with meta-analysis, together with the review of possible mechanisms, provides a better explanation of the impact of classic EDCs on sperm quality. However, future research is needed to examine the following: (1) the biomarker of testis function and human fertility should be well defined in an epidemiology study, and the analysis of sperm quality parameters need to be normalized; (2) the size of adequate samples, occupational exposure to specific EDCs, longitudinal instead of cross-sectional studies, and multi-center studies need to be conducted; (3) due to potential interactions between different EDCs on sperm quality, co-exposure to mixtures of EDCs, as well as their interactions or combined effects should be investigated; (4) for a better understanding of classic EDC-induced abnormal sperm quality, mechanism studies should be focused on low-dose, long-term, and co-exposure; and (5) both human studies and animal experiments are needed on transgenerational effects (e.g. DNA methylation) of EDCs because epigenetic effects as a result of EDC exposure can subsequently change the sperm quality of future generations.

https://www.nature.com/articles/srep19982

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