Dr. Bray Links

Saturday, April 7, 2018

Intestinal microbiota as a tetrahydrobiopterin exogenous source

We further confirmed that at least two PTPS-2-producing species, Aldercreutzia equolifaciens and Microbacterium schleiferi, generate BH4 and are present in hph-1 fecal material. In conclusion, intestinal Actinobacteria generate BH4. This finding has important translational significance, since manipulation of the intestinal flora in individuals with congenital biopterin deficiency may allow for an increase in total body BH4 content.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227711/#!po=1.16279