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Tuesday, January 23, 2018

APOE4 Carriers Also Reap Cognitive Benefits of Healthy Lifestyle Changes

In subgroup analyses of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) study, the cognitive benefits of the multipronged intervention targeting diet, exercise, cognitive training, and vascular risk factors did not significantly differ between apolipoprotein E (APOE) ε4 carriers and noncarriers and might actually be more pronounced in APOE ε4 carriers.

"This is good news for people who worry that genetic risk factors for dementia may somehow hinder potential benefits from healthy lifestyle changes," Alina Solomon, MD, PhD, from the Institute of Clinical Medicine/Neurology, University of Eastern Finland in Kuopio, told Medscape Medical News.


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