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Thursday, December 28, 2017

Low-Normal Thyroid Implicated in Unexplained Infertility

A slightly underactive thyroid gland, the low end of normal, may help to explain some infertility of unknown cause, according to findings of a cross-sectional study published online in the Journal of Clinical Endocrinology & Metabolism.

Specifically, nearly twice as many women with unexplained infertility (26.9%) had a thyroid-stimulating hormone (TSH) level greater than 2.5 mIU/L compared with control patients with normal fertility (13.5%) (P < .05), and on average, those with unexplained infertility showed higher than normal levels of TSH, which is usually elevated in women with underactive thyroid glands.

The study was led by Tahereh Orouji Jokar, MD, from Massachusetts General Hospital and Harvard Medical School in Boston, Massachusetts.

Importantly, write the authors, "All of the subjects in this study had TSH levels within the normal, pre-pregnancy reference range, suggesting that even mild variations of thyroid dysfunction within the normal range may be an important factor in fertility in women who have no known cause for their infertility."


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