Higher levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) are associated with a decreased risk for Parkinson's disease (PD) in men, a large observational study shows.
The results represent the latest research linking higher cholesterol with lower risk for PD.
The new findings suggest that a "one-size-fits-all" approach in clinical practice "overlooks the possible benefits" of higher serum cholesterol levels in some patients, study author Chava Peretz, PhD, professor, School of Public Health, Faculty of Medicine, Tel Aviv University, Israel, told Medscape Medical News.
"Tailoring individualized therapeutic strategies based on stratifying risk and personal background is important," he said.
Dr Peretz's research team presented their study at the International Congress of Parkinson's Disease and Movement Disorders (MDS) 2017.
Higher levels of serum cholesterol are well-established risk factors for coronary artery disease and stroke, but whether cholesterol levels have a similar effect in PD "remains elusive," said Dr Peretz.
"Previous studies on cholesterol and PD risk ignored the changes in cholesterol levels over time, considered only a fixed one-time cholesterol measure, and used small samples. Our study is a big-data study that included a large-scale cohort with a long follow-up time."