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Wednesday, April 12, 2017

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models

However, the wide range of direct effects of tetracycline use has not been fully appreciated. We show here that these antibiotics induce a mitonuclear protein imbalance through their effects on mitochondrial translation, an effect that likely reflects the evolutionary relationship between mitochondria and proteobacteria. Even at low concentrations, tetracyclines induce mitochondrial proteotoxic stress, leading to changes in nuclear gene expression and altered mitochondrial dynamics and function in commonly used cell types, as well as worms, flies, mice, and plants. 

http://www.cell.com/cell-reports/abstract/S2211-1247(15)00180-1

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