Dr. Bray Links

Wednesday, April 12, 2017

Ototoxicity - Tetracyclines

Antibiotics in the aminoglycoside class, such as gentamicin and tobramycin, may produce cochleotoxicity through a poorly understood mechanism.[8] It may result from antibiotic binding to NMDA receptors in the cochlea and damaging neurons through excitotoxicity.[9]Aminoglycoside-induced production of reactive oxygen species may also injure cells of the cochlea.[10] Once-daily dosing[11] and co-administration of N-acetylcysteine[12] may protect against aminoglycoside-induced ototoxicity. The anti-bacterial activity of aminoglycoside compounds is due to inhibition of ribosome function and these compounds similarly inhibit protein synthesis by mitochondrial ribosomes because mitochondria evolved from a bacterial ancestor.[13] Consequently, aminoglycoside effects on production of reactive oxygen species as well as dysregulation of cellular calcium ion homeostasis may result from disruption of mitochondrial function.[14


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