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Thursday, March 30, 2017

Metformin Linked to Dementia, Parkinson's in Patients With T2DM

VIENNA, Austria — Long-term use of the diabetes medication metformin may increase the risk for neurodegenerative disease in patients with type 2 diabetes mellitus (T2DM), new research suggests.

In a cohort study that followed about 9300 patients with T2DM in Taiwan for up to 12 years, the risk for Parkinson's disease (PD) or Alzheimer's dementia was more than double during a 12-year period for those who took metformin vs those who did not — even after adjusting for multiple confounders.

In addition, outcome risks increased progressively with higher dosage and longer duration of treatment.


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