Dr. Bray Links

Tuesday, February 21, 2017

Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse β-carotene 15, 15'-monooxygenase

In BCMO1 knockout mice, disruption in BCMO1 leads to hypercarotenemia on a provitamin A-rich, vitamin A-deficient diet and also to changes in lipid metabolism and susceptibility to diet-induced obesity [9]. Pathological effects of mutations in BCMO1 [10] have also been described in humans. Therefore, the catalytic mechanism for this enzyme is of particular interest.


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