FRAMINGHAM, MA — Long-term findings from a famous cohort study challenge the idea that low HDL-cholesterol levels predict raised cardiovascular risk independently of other blood lipid markers and add to doubts about HDL-C per se as a target for therapy.
It suggests that the association between future CV risk and levels of HDL-C, as currently measured in practice, is modified by LDL cholesterol and triglycerides. The predictive power of HDL-C is diminished when measures of either or both of the other markers are high.
"We're not taking away the importance of HDL. We're just putting it into perspective. If you have low HDL but everything else is normal, your risk of CV disease is not elevated," according to lead author Dr Michael Miller (University of Maryland School of Medicine, Baltimore).