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Thursday, January 5, 2017

Effect of natural products on diabetes associated neurological disorders



Diabetes mellitus, a metabolic disorder, is associated with neurological complications such as depression, anxiety, hypolocomotion, cognitive dysfunction, phobias, anorexia, stroke, pain, etc. Traditional system of medicine is long known for its efficient management of diabetes. The current review discusses the scope of some common medicinal herbs as well as secondary metabolites with a special focus on diabetes-mediated central nervous system complications. Literatures suggest that natural products reduce diabetes-mediated neurological complications partly by reducing oxidative stress and/or inflammation or apoptosis in certain brain regions. Natural products are known to modulate diabetes-mediated alterations in the level of acetylcholinesterase, choline acetyltransferase, monoamine oxidase, serotonin receptors, muscarinic receptors, insulin receptor, nerve growth factor, brain-derived neurotrophic factor, and neuropeptide in brain. Further, there are several natural products reported to manage diabetic complications with unknown mechanism. In conclusion, medicinal plants or their secondary metabolites have a wide scope and possess therapeutic potential to effectively manage neurological complications associated with chronic diabetes.

Medicinal plants:
  • Allium sativum (Amaryllidaceae)
  • Aloe vera (Xanthorrhoeaceae)
  • Anemarrhenae rhizome (Liliaceae)
  • Bacopa monnieri (Scrophulariaceae)
  • Cassia auriculata (Fabaceae)
  • Cinnamomum zeylanicum (Lauraceae)
  • Cleome viscose (Capparaceae)
  • Crocus sativus (Iridaceae)
  • Folium mori (Moraceae)
  • Ginkgo biloba (Ginkgoaceae)
  • Gymnema montanum (Asclepiadaceae)
  • Mesembryanthemum crystallinum (Aizoaceae)
  • Momordica charantia (Cucurbitaceae)
  • Ophiocordyceps formosana (Ophiocordycipitaceae)
  • Pouteria ramiflora (Sapotaceae)
  • Punica granatum (Punicaceae)
  • Syzigium cumini (Myrtaceae)
  • Teucrium polium (Lamiaceae)
  • Trigonella foenum graecum (Fabaceae)
  • Withania somnifera (Solanaceae)
  • Zingiber Officinalis (Zingiberaceae)

Role of secondary metabolites on diabetes-mediated neurological complications:

  • Bromocryptine
  • Chlorogenic acid
  • Chrysin
  • Dihydromyricetin
  • Epigallocatechingallate (EGCG)
  • Fisetin
  • Gallic acid
  • Genistein
  • Hesperidin
  • Huperzine A
  • Icariin
  • Luteolin
  • Morin
  • Oxymatrine
  • Pelargonidin
  • Pregabalin
  • Procyanidin
  • Rutin
  • Silibinin
  • Troxerutin


https://www.ncbi.nlm.nih.gov/pubmed/28030360

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