PharmaGABA is manufactured via a fermentation process that utilizes the probiotic Lactobacillus hilgardii. This natural form has been shown to produce effects not achieved by the synthetic form of GABA, which is produced from pyrrolidinone – an industrial solvent. PharmaGABA has been shown to produce relaxation as evidenced by:
• Increasing the alpha to beta brain wave ratio.
• Preserving salivary antibody production during stress.
• Reducing markers of stress including cortisol levels.
• Improve sleep quality as noted by an ability to decrease the time required to go to sleep, promote proper sleep rhythm, and increase the time spent in both deep sleep stages and REM sleep.
Once ingested, it is absorbed easily and binds to GABA receptors outside the brain that ultimately lead to activation of the parasympathetic nervous system. This arm of the autonomic nervous system is responsible for producing what is referred to as the "relaxation response," a physiological response that is in direct contrast to the stress or "fight or flight" response. This activation of the parasympathetic nervous system by PharmaGABA is measurable within 5 to 30 minutes after ingestion.
There is evidence that PharmaGABA may increase growth hormone (GH) secretion in response to weight lifting exercise. Since GH is an important regulator of body composition including muscle protein synthesis, GABA may enhance the muscle building effects of protein ingestion after weight lifting exercise. To test this hypothesis in a double-blind clinical trial conducted in Japan, 26 healthy male volunteers were divided into two groups: whey protein 10 g/day (WP group), or whey protein 10 g/day + GABA 100 mg/day (WP+G) group. After 12 weeks, change in whole body lean mass was significantly higher in WP+G group compared to that in WP group. The difference in whole body lean mass in the WP+G compared to WP alone is substantial.