Dr. Bray Links

Saturday, January 30, 2016

Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects


Tetrahydrobiopterin (BH4) is an essential cofactor required for the activity of endothelial nitric oxide (NO) synthase. Suboptimal concentrations of BH4 in the endothelium reduce the biosynthesis of NO, thus contributing to the pathogenesis of vascular endothelial dysfunction. Supplementation with exogenous BH4 or therapeutic approaches that increase endogenous amounts of BH4 can reduce or reverse endothelial dysfunction by restoring production of NO. Improvements in formulations of BH4 for oral delivery have stimulated clinical trials that test the efficacy of BH4 in the treatment of systemic hypertension, peripheral arterial disease, coronary artery disease, pulmonary arterial hypertension, and sickle cell disease. This review discusses ongoing progress in the translation of knowledge, accumulated in preclinical studies, into the clinical application of BH4 in the treatment of vascular diseases. This review also addresses the emerging roles of BH4 in the regulation of endothelial function and their therapeutic implications.

http://www.sciencedirect.com/science/article/pii/S0165614708002435

http://www.nature.com/npp/journal/v37/n1/full/npp2011205a.html

1 comment:

  1. Hello, am Tanya Albert from United State. am happy sharing this great testimony on how i was checking for solution in the internet then miraculously i came Across Dr Ekpiku, the powerful herbalist that Cure Numerous individuals HSV-1 AND HSV-2 INFECTION,then i contacted his Email: (ekpikuspellhomeofgrace@gmail.com) I Explained everything to him and he prepared me a herbal medicine that cure my HSV-1 AND HSV-2 Disease totally after making use his herbal medicine, So My friends viewers why wait and be suffer when there is someone like Dr Ekpiku, that can cure any disease HIV/ CANCER/ HEPATITIS B VIRUS,LOW SPERM COUNT, ALS , ANCE PIMPUS , LUPUS VIRUS, You Can "CONTACT him Via : Email : (ekpikuspellhomeofgrace@hotmail.com) or call +16506538578 You Can Contact Him Today And Get Your Problem Solved.

    ReplyDelete