India Study: Acne Associated With Metabolic Abnormalities
The Indian study was cross-sectional and involved 100 male patients with acne and 100 age-matched male controls without acne. Participants were recruited from a dermatology outpatient department of a tertiary-care institute. Insulin resistance was measured using the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) measure, while the metabolic syndrome was diagnosed using criteria from the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III).
It is noteworthy that among men in India, a BMI of 23 through to 24.9 kg/m2 is considered overweight while a BMI of 25 through 29.9 kg/m 2 is considered to be moderately obese.
As Dr Nagpal and colleagues report, the mean HOMA-IR value in men with acne was significantly higher, at 2.0, than in controls, at 1.7 (P = .049), while insulin resistance — arbitrarily predefined as a HOMA-IR value greater than 2.5 — was detected in 22% of men with acne compared with 11% of controls, which was significantly different (P = .036).