Although numerous treatments for various forms of arthritis have been identified, they suffer from various drawbacks, such as lack of efficacy, excessive side effects and high cost. Usually, treatment of arthritis requires treatment of the patient for their entire lifetime, and so these drawbacks are significant. Plant-derived products offer much promise but they require extensive investigation in various preclinical and clinical settings to prove their usefulness. Owing to the lack of intellectual property rights, the industry currently has little motivation to pursue such studies. Hopefully, federal agencies will provide the financial backing to support such studies. Thus, natural products serve as a gold mine for the treatment of arthritis.