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Monday, October 5, 2015

Placebo Effect a Major Factor in Antidepressant Response


"Placebo response rates in depression are as high as 50%, which is pretty close to the response rates we see with antidepressant therapy, so it's important to understand placebo responses because they account for an important proportion of the actual response to antidepressant treatment," Marta PeciƱa, MD, PhD, University of Michigan, in Ann Arbor, told Medscape Medical News.

"Basically, we've shown that the mu-opioid system — our own endogenous opioids — are associated with the formation of the placebo response [in depression] and that this occurs in regions of the brain that are involved in emotional regulation and the biology of depression."

The study was published online September 30 in JAMA Psychiatry.

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