Friday, September 18, 2015
These Men Ate 6,000 Calories A Day To See How Obesity Leads To Diabetes
Samples of the participants' urine and fat tissue showed that there was an increase in oxidative stress in their bodies, which means there was an increase in compounds that are toxic to cells. This oxidative stress caused changes in a protein called GLUT4, which normally helps sugar get inside cells.
The GLUT4 changes may have impaired the ability of this protein to respond to the hormone insulin, thus leading to insulin resistance, the researchers said.
"We may have found the initial events that are responsible for the insulin resistance," said study researcher Salim Merali, a professor of pharmaceutical sciences at Temple University in Philadelphia.
The new findings suggest that treatments that use antioxidants might help prevent insulin resistance, Merali said.