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Friday, September 4, 2015

Multiple Autoimmune Diseases Share Same Genetic Risk Factors

The 10 clinically distinct pAIDs included in the analysis were type 1 diabetes, celiac disease, juvenile idiopathic arthritis, common variable immunodeficiency disease, systemic lupus erythematosus, Crohn's disease, ulcerative colitis, psoriasis, autoimmune thyroiditis, and ankylosing spondylitis.

The investigators traced the identified signals to genes known to be involved in various immune-related pathways, including cytokine signaling, antigen processing and presentation, T-cell activation, JAK-STAT activation, and TH1-, TH2-, and TH17-associated cytokine signaling.

"Of these pathways, JAK2 signaling was particularly compelling," the authors write, noting that this finding is consistent with the enrichment of known protein–protein interactions. "We also uncovered evidence supporting shared genetic susceptibility for disease pairs that have not yet been well established."

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