Dr. Bray Links

Saturday, April 25, 2015

Mycoplasma Testing


The top three pathogens that Chronic Fatigue Syndrome and Fibromyalgia patients on the Mycoplasma Registry test positive for using PCR blood tests:
  1. Mycoplasma fermentans (incognitus strain and various other strains) 
  2. Human Herpes Virus-6a (HHV-6a) 
  3. Chlamydia pneumoniae ("Chronic Chlamydia pneumoniae infection")
Others pathogens found:

  • Mycoplasma pneumoniae
  • Mycoplasma hominis
  • Ureaplasma urealyticum
  • Mycoplasma genitalium
  • Mycoplasma penetrans
  • Borrelia burgdorferi ("Chronic Lyme Disease" may cause or trigger fibromyalgia) 
  • Brucellosis ("Chronic Brucellosis")
Rickettsia Diseases:
  • Coxiella burnetii (Q-Fever and "Post-Q Fever Fatigue Syndrome") Staphylococcus
  • Epstein-Bar Virus (reactivation) 
  • Coxsackie B Viruses(1-6)("Chronic Coxsackie Infection" may cause or trigger fibromyalgia, myalgias and other diseases.) 
  • Parvovirus B19("Chronic Parovirus Infection" may cause or trigger fibromyalgia, arthralgia, arthritis) 
  • Enteroviruses (causes: "Chronic inflammatory muscle disease"or fibromyalgia) 
  • Cytomegalovirus 
  • Borna Disease virus 
  • Cytocidal Viruses 
  • Hepatitis C ("Chronic Hepatitis C" may cause or trigger fibromyalgia)

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The Gulf War Mycoplasma Study showed that nearly all the Gulf War veterans who tested positive for mycoplasma infections were positive for Mycoplasma fermentans. Mycoplasma genitalium was also found and a very small percentage tested positive for Mycoplasma pneumoniae.

We recommend that all Gulf War veterans also get tested for: uranium poisoning from exposure to depleted uranium, antibodies to experimental vaccine adjuvants such as squalene, and if there has been any exposure to organophosphate pesticides or sarin nerve gas get tested for the blood enzyme, paraoxonase.

In addition, Veterans have experience long term side effects from prescription drugs such as:
pyridostigmine bromide, given to troops to protect against nerve gas, and the antimalarial drug Lariam (mefloquine).

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  • Mycoplasma penetrans
  • Mycoplasma pirum
  • Mycoplasma fermentans (incognitus strain)
  • Mycoplasma fermentans (various other strains)
  • Mycoplasma hominis
  • Mycoplasma genitalium
  • Mycoplasma pneumoniae
  • Ureaplasma urealyticum
  • Human Immunodeficiency Virus (HIV)
  • Human Herpes Virus-6a (HHV-6a)
  • Cytomegalovirus
  • Herpes Simplex virus
  • Enterovirus
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If bitten by ticks or fleas carrying Borrelia burgdorferi you can develop traditional Lyme Disease, which is self-limiting and carried by a deer tick. Our experience with patients suggests that if the tick or flea also carries co-infections, such as Babesiosis or especially Mycoplasmas, you may develop "Chronic Lyme Disease" also known as "New Lyme Disease" as well as Chronic Fatigue Syndrome, Fibromyalgia and Autoimmune Diseases.

"Montana Lyme Disease" symptoms are similar to Lyme Disease. However, it is caused by a Lyme disease-like agent that has adapted to the Rocky Mountain wood ticks found in Montana and the Western United States.

"Chronic Lyme Disease" is a combination of the pathogen:
Lyme Disease and one or more of the following Co-infections:
Spirochetes (Borrelia bacteria):
Lyme Disease caused by three types of Spirochete Borrelia bacteria:
Borrelia burgdorferi sensu stricto (USA, UK, Europe)
Borrelia garinii (UK, Europe)
Borrelia afzelii. (UK, Europe)

Relapsing Fever caused by the spirochetes:
  • Borrelia hermsii 
  • Borrelia turicatae
  • Mycoplasma fermentans
  • Mycoplasma pneumoniae
  • Chlamydia pneumoniae
Rickettsial Diseases: 
  • Rocky Mountain Spotted Fever 
  • Coxiella burnetti (Q-Fever and "Post-Q Fever Fatigue Syndrome")
  • Colorado Tick Fever
  • Eastern tick-borne Rickettsiosis 
  • Rickettsialpox
  • Tularemia (rabbit fever) 
  • Ehrlichiosis (caused by Ehrlichia, a rickettsia-like bacteria)
  • Anaplasmas (related to the genera Rickettsia and Ehrlichia)
  • Babesia microti 
  • Babesia WA-1
  • Hepatitis-C 
  • Bartonella henselae (cat scratch fever)
  • Bartonella quintana (trench fever)
  • Viral Meningitis

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POST-POLIO SYNDROME (PPS) & "Non-Paralytic" Polio

PCR Biopsy - An antibody test is not useful since it can not differentiate between an active infection, reactivated infection or antibodies from polio vaccines. However, a PCR test can be done on biopsied tissue and examined under a microscope to determine if there new polio virus or reactivated polio virus. Other viruses associated with PPS and NPP to test for:

ECHO viruses
Enteroviruses 71
Coxsackie virus A7 ("Polio virus Type IV")
Coxsackie B viruses (1-6)

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1. INDIVIDUAL: The most accurate of the PCR blood tests is the individual test for a specific species.

2. "MULTIPLEX": Multi-species ("3 in 1" or "4 in 1") mycoplasma PCR blood tests are less expensive but their accuracy rate may not be as high as individual species tests. Therefore, patients need to specifically ask the laboratories for the published accuracy rate of their "multiplex" tests. Additionally, some laboratories identify a combination of tests for one price as a "panel" when in fact they are performing a "multiplex" test.

3. ANTIBODY TEST: The least accurate of the blood tests. In the case of Mycoplasma fermentans (incognitus), antibodies are not produced until the patient is near death. However, antibodies to the other mycoplasma species are produced more readily.

4. CULTURE: Mycoplasmas are rarely successfully cultured, as they require specialized culture mediums and weeks of careful laboratory work. In some rare instances, culturing may be an alternative choice.



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