Dr. Bray Links

Tuesday, October 14, 2014

Gluten sensitivity and intestinal hyperpermeability ("leaky gut")


Gluten (from wheat, rye, and barley) is said to be the #1 trigger for development of autoimmune disease. Take the test to see if you have gluten sensitivity.

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Gluten Sensitivity Self-Test
http://www.doctoroz.com/article/gluten-sensitivity-self-test

As many as 20 million Americans could be affected by a gluten sensitivity and not know it. Find out if you might be experiencing a gluten sensitivity with this checklist. Count all the symptoms that you experience on a regular, chronic basis.

Digestive Symptoms
•Frequent bloating or gas
•Diagnosed with IBS or acid reflux
•Daily diarrhea or chronic constipation

Neurologic & Skeletal Symptoms
•Migraine or headaches
•Joint pains or aches
•Brain fog

Hormonal & Immune Symptoms
•Depression or anxiety
•Ongoing fatigue
•Chronic eczema or acne

Results
Four or more symptoms indicate that gluten may be impacting your health. But even one symptom, if severe and chronic, can be a sign of a gluten sensitivity. You may want to try going gluten-free for 2-4 weeks.

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"Gluten Sensitivity: Real Disorder, Real Symptoms
There’s a lot of confusion about gluten sensitivity. Some say it doesn’t exist. Others think going gluten free without celiac disease is unnecessary and is just a fad. But science now confirms what gluten sensitive patients and their doctors have known for years: Gluten sensitivity is a real disorder with defined symptoms that can affect any part of the body.  Read More

Predicting and Preventing Autoimmunity, Myth or Reality?
Taken as a group, autoimmune diseases are the third leading cause of morbidity and mortality in the industrialized world, only surpassed by cancer and heart disease. Many autoimmune diseases are chronic diseases that progress over the course of years and are characterized by the presence of autoantibodies that precede the overt disease. Autoantibodies may also predict specific clinical manifestation, disease severity, and rate of progression, as well as specific clinical phenomena, such as autoimmune pregnancy loss. Read More

The Mosaic of Autoimmunity: Prediction, Autoantibodies, and Therapy in Autoimmune Diseases – 2008
The most significant development in our understanding of autoimmunity in the last 5 years relates to our ability to predict autoimmune diseases. Predictivity of autoimmunity For more than two decades, the detection of serum autoantibodies has been used for the diagnosis and classification of autoimmune diseases. In addition, some autoantibodies have a prognostic significance or are used as markers for disease activity. In recent years a new piece in the mosaic of autoimmunity has clearly emerged – namely, the predictive value of autoantibodies. Read More

The Conundrum of Gluten Sensitivity 101: Why the Tests are Often Wrong
In this 4-part Series, we’re going to look at the World of Gluten Sensitivity, what the current science tells us, the frustrations Gluten Sensitive and Celiac patients often experience, and how to use the science in getting healthier. ……: “That gluten sensitivity is regarded as principally a disease of the small bowel is a historical misconception.1” There is a key word in this statement which I suspect was an emphasis of the Author’s message and sets the tone for this article (and this Network Movement). That key word is ‘principally’. Is Gluten Sensitivity ‘principally’ a disease of the small intestine? Point-blank answer-no, it is not. For every Gluten Sensitive patient with the symptoms of an enteropathy (Classic Celiac Disease), there are 8 with no GI symptoms2 3.

New Gluten Sensitivity and Related Testing from Cyrex Labs is now available.
Over the last few years, we have seen the correlation of Gluten Sensitivity as a common initiator of multiple pathologies.  From Attention Deficit Hyperactivity Disorder to Hepatocellular Carcinoma, from Migraines to Recurrent Pancreatitis, from Cardiomyopathy to numerous autoimmune diseases, we have seen the association of sensitivity to this protein of wheat, rye and barley with the initial manifestation of multiple pathophysiologies.

But there’s been a Conundrum. What is it?  Problems associated with standard tests for Gluten Sensitivity.
The only blood tests (until now) for Celiac Disease have been extremely accurate and dependable if a person has Total Villous Atrophy (TVA).  However, when biopsy test results with anything less than TVA, the accuracy of the test drops tremendously (to as low as being wrong 7 out of 10 times).  Would you tolerate that accuracy rate for a cancer, heart disease, or even pregnancy test? Gluten has to have significantly destroyed the gut wall for current blood testing to be effective.  For the majority of people that isn’t the case…especially if the brain, heart, liver, or some other part of the body is the main target of attack."

http://thedr.com/category/all-about-gluten/articles/

http://glutensummit.org/

The BEST testing for gluten sensitivity and "leaky gut":
http://www.cyrexlabs.com/CyrexTestsArrays/tabid/136/Default.aspx

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