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Wednesday, October 22, 2014

Fatty Fish May Boost Antidepressant Response

<<Fatty Fish May Boost Antidepressant Response
Deborah Brauser
October 22, 2014

BERLIN ― Alterations in fatty acid (FA) metabolism and the way it is regulated by cortisol may be linked to response to antidepressant treatment in patients with major depressive disorder (MDD). In addition, increasing fatty fish intake may "boost" treatment response, new research suggests.

A study of 121 adults showed that those with MDD had higher adjusted levels of arachidonic acid (AA), as well as higher FA unsaturation and FA peroxidation, than their healthy peers.

In addition, within the MDD group, nonresponders to the selective serotonin reuptake inhibitor (SSRI) paroxetine (multiple brands) had significantly different concentrations of AA and eicosapentenoic acid (EPA)/AA than early or late responders, as well as lower levels of omega-3 docosahexanenoic acid (DHA).
However, these relationships were mediated by fish intake. The MDD group members who ate fatty fish at least once a week had a 75% increased chance of antidepressant response vs a 23% response rate for those who never ate fatty fish.

"This suggest that we could use arachidonic acids as an indicator of response, and that it might be worthwhile to target fatty acid metabolism to increase response rates to SSRIs," lead author Roel J. T. Mocking, PhD candidate from the Department of Psychiatry of the Academic Medical Center at the University of Amsterdam, the Netherlands, told Medscape Medical News.

"I think the take-away is that adding fatty fish offers benefits. There's no downside to recommending this to patients. It's good to eat two servings of fish a week, with one being fatty fish. And for patients [with MDD], it's like it boosts their response," said Mocking.

The study was presented here at the 27th European College of Neuropsychopharmacology (ECNP) Congress.>>

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