Wednesday, September 24, 2014
Persistent Organic Pollutants (POPs)
"The evidence base supporting a link between persistent organic pollutant exposure and a wide spectrum of diseases continues to grow, particularly for cardiometabolic and neurological conditions. These lipophilic and stable substances include a range of substances, such as polychlorinated biphenyls (PCBs), organochlorine pesticides, polybrominated diphenyl ethers (PDBEs), plastics, phthalates, polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs), many of which are widespread globally. ...
At least part of their toxicity appears to be mediated via epigenetic mechanisms, which now appear to be on par with genetic polymorphisms for clinical importance. Unlike genetic mutations, epigenetic modifications appear to be reversible with appropriate interventions. While much remains to be determined, avoidance of exposure seems highly indicated, as does nutritional support of relevant metabolic pathways, including glutathione synthesis and methylation, particularly during crucial periods of development."