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Thursday, September 21, 2017

The neurological significance of abnormal natural killer cell activity in chronic toxigenic mold exposures. - PubMed - NCBI

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ScientificWorldJournal. 2003 Nov 13;3:1128-37.
The neurological significance of abnormal natural killer cell activity in chronic toxigenic mold exposures.
Anyanwu E1, Campbell AW, Jones J, Ehiri JE, Akpan AI.
Author information
Abstract

Toxigenic mold activities produce metabolites that are either broad-spectrum antibiotics or mycotoxins that are cytotoxic. Indoor environmental exposure to these toxigenic molds leads to adverse health conditions with the main outcome measure of frequent neuroimmunologic and behavioral consequences. One of the immune system disorders found in patients presenting with toxigenic mold exposure is an abnormal natural killer cell activity. This paper presents an overview of the neurological significance of abnormal natural killer cell (NKC) activity in chronic toxigenic mold exposure. A comprehensive review of the literature was carried out to evaluate and assess the conditions under which the immune system could be dysfunctionally interfered with leading to abnormal NKC activity and the involvement of mycotoxins in these processes. The functions, mechanism, the factors that influence NKC activities, and the roles of mycotoxins in NKCs were cited wherever necessary. The major presentations are headache, general debilitating pains, nose bleeding, fevers with body temperatures up to 40 degrees C (104 degrees F), cough, memory loss, depression, mood swings, sleep disturbances, anxiety, chronic fatigue, vertigo/dizziness, and in some cases, seizures. Although sleep is commonly considered a restorative process that is important for the proper functioning of the immune system, it could be disturbed by mycotoxins. Most likely, mycotoxins exert some rigorous effects on the circadian rhythmic processes resulting in sleep deprivation to which an acute and transient increase in NKC activity is observed. Depression, psychological stress, tissue injuries, malignancies, carcinogenesis, chronic fatigue syndrome, and experimental allergic encephalomyelitis could be induced at very low physiological concentrations by mycotoxin-induced NKC activity. 

https://www.ncbi.nlm.nih.gov/pubmed/14625399

Clinical Diagnosis of the Dampness and Mold Hypersensitivity Syndrome: Review of the Literature and Suggested Diagnostic Criteria. - PubMed - NCBI

A great variety of non-specific symptoms may occur in patients living or working in moisture-damaged buildings. In the beginning, these symptoms are usually reversible, mild, and present irritation of mucosa and increased morbidity due to respiratory tract infections and asthma-like symptoms. Later, the disease may become chronic and a patient is referred to a doctor where the assessment of dampness and mold hypersensitivity syndrome (DMHS) often presents diagnostic challenges. Currently, unanimously accepted laboratory tests are not yet available. Therefore, the diagnosis of DMHS is clinical and is based on the patient's history and careful examination. In this publication, I reviewed contemporary knowledge on clinical presentations, laboratory methods, and clinical assessment of DMHS. From the literature, I have not found any proposed diagnostic clinical criteria. Therefore, I propose five clinical criteria to diagnose DMHS: (1) the history of mold exposure in water-damaged buildings, (2) increased morbidity to due infections, (3) sick building syndrome, (4) multiple chemical sensitivity, and (5) enhanced scent sensitivity. If all the five criteria are met, the patient has a very probable DMHS. To resolve the current problems in assigning correct DMHS diagnosis, we also need novel assays to estimate potential risks of developing DMHS.

https://www.ncbi.nlm.nih.gov/pubmed/28848553

Non-Thyroidal Illness Syndrome in Patients Exposed to Indoor Air Dampness Microbiota Treated Successfully with Triiodothyronine. - PubMed - NCBI

Long-term exposure to dampness microbiota induces multi-organ morbidity. One of the symptoms related to this disorder is non-thyroidal illness syndrome (NTIS). A retrospective study was carried out in nine patients with a history of mold exposure, experiencing chronic fatigue, cognitive disorder, and different kinds of hypothyroid symptoms despite provision of levothyroxine (3,5,3',5'-tetraiodothyronine, LT4) monotherapy. Exposure to volatile organic compounds present in water-damaged buildings including metabolic products of toxigenic fungi and mold-derived inflammatory agents can lead to a deficiency or imbalance of many hormones, such as active T3 hormone. Since the 1970s, the synthetic prohormone, levothyroxine (LT4), has been the most commonly prescribed thyroid hormone in replacement monotherapy. It has been presumed that the peripheral conversion of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) is sufficient to satisfy the overall tissue requirements. However, evidence is presented that this not the case for all patients, especially those exposed to indoor air molds. This retrospective study describes the successful treatment of nine patients in whom NTIS was treated with T3-based thyroid hormone. The treatment was based on careful interview, clinical monitoring, and laboratory analysis of serum free T3 (FT3), reverse T3 (rT3) and thyroid-stimulating hormone, free T4, cortisol, and dehydroepiandrosterone (DHEA) values. The ratio of FT3/rT3 was calculated. In addition, some patients received adrenal support with hydrocortisone and DHEA. All patients received nutritional supplementation and dietary instructions. During the therapy, all nine patients reported improvements in all of the symptom groups. Those who had residual symptoms during T3-based therapy remained exposed to indoor air molds in their work places. Four patients were unable to work and had been on disability leave for a long time during LT4 monotherapy. However, during the T3-based and supportive therapy, all patients returned to work in so-called "healthy" buildings. The importance of avoiding mycotoxin exposure via the diet is underlined as DIO2 genetic polymorphism and dysfunction of DIO2 play an important role in the development of symptoms that can be treated successfully with T3 therapy.


https://www.ncbi.nlm.nih.gov/pubmed/28824644

New Rules Required to Curb Childhood Obesity

 Three inexpensive programs have proven to be the most cost-effective ways to reduce childhood obesity rates, results from the Childhood Obesity Intervention Cost-Effectiveness Study (CHOICES) show.

The work has provided clear evidence that the interventions save more than they cost to implement, said investigator Steven Gortmaker, PhD, from the Harvard T.H. Chan School of Public Health in Boston.

"That's extraordinary," he said here at the American Academy of Pediatrics 2017 National Conference and Exhibition. "These are actual cost-saving interventions."

Dr Gortmaker and his colleagues assessed more than 40 programs on the national agenda by examining evidence reviews from some 130,000 peer-reviewed publications. The team used big data and microsimulation models to project the impact of interventions and their cost-effectiveness over the decade from 2015 to 2025, taking into account trends across states and populations.

The first intervention is the imposition of an excise tax — $0.01 per ounce — on sugar-sweetened beverages. This has been shown to reduce consumption and is inexpensive to implement because tax systems are already in place. Projected savings of about $14 billion come from the slower rise in obesity rates induced by the tax, and do not include the expected $12.5 billion increase in national tax revenue.


http://www.medscape.com/viewarticle/885984

Dietary Supplement With Ketones May Mitigate Migraine Attacks

"We know that ketone bodies are not only metabolized, they're also signaling molecules. First of all, they're a more efficient fuel than glucose. Per molecule, they produce a lot more ATP [adenosine triphosphate] than a molecule of glucose," she said. "They also induce mitochondrial biogenesis, [and] they're very potent reactive oxygen species inhibitors.

Further, they produce less oxidative stress per molecule burned and reduce brain excitability, she added. "They shift the equilibrium between glutamate and GABA [γ-aminobutyric acid] in the direction of GABA, and they also have an influence on glutamate transport itself."

She went on to note that supplying more KBs increases ketone body transporter mechanisms, they are anti-inflammatory, and they reduce blood glucose levels. "So they have a variety of potential migraine-relevant mechanisms in addition to being a more effective fuel" than glucose.

She and her colleagues have started enrolling patients with migraine in a double-blind, randomized, placebo-controlled trial (NCT03132233) to test the bHB supplement in a crossover design over 3 months in a group of 90 participants.

The impetus for this work was the fact that Gross developed migraines in her mid-teens, and she said she wants something that will work for her and for many other patients with migraine. The side effects of currently approved prophylactic drugs are "intolerable for most patients," she said, and avoiding food and lifestyle triggers of migraines severely limits ones activities and life.

http://www.medscape.com/viewarticle/886000

Sunday, September 17, 2017

Nickel allergy: How to avoid exposure and reduce symptoms | American Academy of Dermatology

Avoid foods containing nickel if you are extremely sensitive to nickel. Some foods that contain high amounts of nickel include soy products—such as soybeans, soy sauce, and tofu—licorice, buckwheat, cocoa powder, clams, cashews, and figs.

https://www.aad.org/public/diseases/rashes/nickel-allergy

Frame Materials and Metal Allergies

The most common cause of metal allergies is mercury, and this is followed by metals including nickel, cobalt, tin, palladium and chrome.Conversely, metals such as gold, titanium, silver and iron are less likely to produce allergic reactions since they rarely dissolve upon contact with perspiration or other bodily fluids.

Of the metals most likely to produce allergic reactions, nickel is the one that is most commonly used in spectacle frames. For a long time, nickel has been used in the form of an alloy as a material for spectacle frames and is also used as the base plating material for plating and gold plating, for example. 

Compared with other metals, the properties of nickel make it readily dissolvable, and this means that contact of the body with nickel will result in the metal beginning to dissolve due to the effect of sodium ions in perspiration, causing an allergic reaction.

However, as a recent measure to prevent allergic reactions, the materials used in many products on the market nowadays are nickel-free. In addition, frames with vinyl-covered temples are now available for people with metal allergies.

People who may have metal allergies are recommended to undergo a patch test at a dermatologist. Forearmed with knowledge of which metals are likely to cause an allergic reaction, you will know which metals to avoid when purchasing spectacles.

http://seikoeyewear.com/eye-information/about-frames/materials-metal-allegries

Nickel Allergies on Rise as Devices Meet Skin - NYTimes.com

Nickel, one of the most common allergens in the United States, can be found in things like hand-held devices and jewelry. But unlike Europe, the United States has no restrictions on its widespread use in consumer products. That worries some doctors who say that the growing use of mobile and hand-held devices combined with a lack of regulatory oversight could lead to a spike in allergic reactions.

"I am absolutely concerned about it," said Stephen P. Stone, the director of clinical research in dermatology at the Southern Illinois University School of Medicine and the former president of the American Academy of Dermatology.

The Centers for Disease Control and Prevention estimates that 10 to 20 percent of the population is allergic to nickel. The reactions can be unpleasant, but not fatal. Typically they include blistering, redness and dry skin.



https://mobile.nytimes.com/2014/08/21/technology/personaltech/nickel-allergies-on-rise-as-devices-meet-skin.html?referer=https://duckduckgo.com/

Wednesday, September 13, 2017

Fire Retardants Found in Furniture and Gym Mats Implicated in Infertility

PFRs are commonly added to polyurethane foam, gym mats and baby items such as car seats, ostensibly to reduce the risk of the items catching fire. However, the chemicals do not remain in these items. They spread, contaminating air and dust. They can also migrate through direct contact. One 2015 study13 found nearly every dust sample collected from American homes contained the flame retardants Tris phosphate and triphenyl phosphate (TPHP).

Ninety-one percent of urine samples from the residents also contained metabolites of Tris phosphate, and 83 percent had metabolites of TPHP. Disturbingly, toddlers have been found to have levels of flame retardants that are as much as five times higher than their mother's.14 Needless to say, bioaccumulation can have serious health consequences over the course of a lifetime, and may ultimately affect the reproductive capacity of coming generations.


http://fitness.mercola.com/sites/fitness/archive/2017/09/08/flame-retardants-health-effects.aspx

Tuesday, September 12, 2017

Exposure to Disinfectants Linked to COPD

This was a "well-performed study," said Lidwien Smit, PhD, from the University of Utrecht in the Netherlands. "I just wonder about the pathology, and how it influences the microbiome."

"Disinfectants are meant to kill off bacteria, but if you're exposed to large concentrations, you're also inhaling them, which could affect your airway microbes," she explained.

In fact, disinfectants could play a role in killing off bacterial communities in the airways that are responsible for "immune homeostasis" and keep users healthy, she added.

If that immune balance gets disturbed, it might have an influence on a person's reaction to pathogens or inflammation. "This is all part of the COPD pathology — that could be another interesting hypothesis to study," Dr Smit told Medscape Medical News.

Dr Dumas is clear that this is preliminary observational research and more studies are needed. Determining which agents are most harmful "would help define guidelines to protect workers," she noted.

The current findings do not show that the disinfectants are a direct cause of COPD, but they do draw an association between some disinfectants and development of the disease. "I hope this study will help open the discussion for better guidelines," Dr Dumas said.

http://www.medscape.com/viewarticle/885575

Saturday, September 2, 2017

The Unexpected and Troubling Rise of Candida auris

Hello. I am Dr Tom Chiller, chief of the Mycotic Diseases Branch at the Centers for Disease Control and Prevention (CDC). As part of the CDC Expert Commentary Series on Medscape, I would like to tell you about Candida auris, a novel yeast that is behaving in unexpected and concerning ways, causing severe disease in countries across the globe, including the United States. Today we'll share how you can protect your patients from this potentially deadly infection, the history of this unusual bug, and how the United States is working with global partners to combat its spread.


http://www.medscape.com/viewarticle/884470

Monday, August 28, 2017

Dark Hair Dye and Chemical Relaxers Linked to Breast Cancer



The study of 4,285 African-American and white women was the first to find a significant increase in breast cancer risk among black women who used dark shades of hair dye and white women who used chemical relaxers.

Black women who reported using dark hair dye had a 51 percent increased risk of breast cancer compared to black women who did not, while white women who reported using chemical relaxers had a 74 percent increased risk of breast cancer, the study found.

The risk of breast cancer was even higher for white women who regularly dyed their hair dark shades and also used chemical relaxers, and it more than doubled for white dual users compared to white women who used neither dark dye nor chemical straighteners.

The association between relaxers and breast cancer in white women surprised lead author Adana Llanos, an epidemiologist at the Rutgers School of Public Health in Piscataway, New Jersey, although she worried enough about the safety of hair relaxers in African-American women like herself to stop using them years ago.

http://www.medscape.com/viewarticle/882833

Sunday, August 27, 2017

HLA-DQ:gluten tetramer test in blood gives better detection of coeliac patients than biopsy after 14-day gluten challenge

A 14-day gluten challenge was not enough to establish significant mucosal architectural changes in majority of patients with coeliac disease (sensitivity ≈25%–50%). Increase in CD4+ effector-memory gut-homing HLA-DQ:gluten tetramer-binding T cells in blood 6 days after gluten challenge is a more sensitive and less invasive biomarker that should be validated in a larger study.

http://gut.bmj.com/content/early/2017/08/04/gutjnl-2017-314461

HPHPA and Clostridia


The dysbiosis marker 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), the predominant dihydroxyphenylpropionic acid isomer in urine, is also measured in the Organic Acids Test offered by The Great Plains Laboratory. This marker was proven by Dr. William Shaw to be due to a combination of human metabolism and the metabolism by a group of Clostridia species, including but not limited to C. difficile.

HPHPA has been one of the most useful clinical markers in recent medical history. Treatment with metronidazole, vancomycin, or high doses of probiotics of individuals with high urinary values has led to significant clinical improvements or remissions of psychosis.

The biochemical role of Clostridia in altering brain neurotransmitters is due to the fact that Clostridia metabolites inactivate dopamine beta-hydroxylase, leading to an excess production of brain dopamine and reduced levels of the neurotransmitter norepinephrine. Excess dopamine is associated with abnormal or psychotic behavior. This imbalance can be demonstrated in the Organic Acids Urine Test by observing the ratio of the major dopamine metabolite, homovanillic acid (HVA), to that of the major norepinephrine metabolite, vanillylmandelic acid (VMA) when the Clostridia marker HPHPA is elevated. After treatment with metronidazole or vancomycin, HPHPA values return to normal along with normal ratios of HVA/VMA and normal behavior.

The highest value of HPHPA was measured in the urine of a young woman with first onset of schizophrenia. Treatment of Clostridia bacteria resulted in loss of auditory hallucinations. In autism, children with gastrointestinal Clostridia commonly exhibit aggressive behavior, agitation, obsessive compulsive behavior, and irritability. They may have very foul stools with diarrhea with mucus in the stools although some individuals may be constipated. Stool testing for Clostridia is usually of limited usefulness since most Clostridia species are considered probiotics or beneficial. There are about 100 species of Clostridia that are commonly found in the gastrointestinal tract. Only seven of these species are producers of HPHPA including C. sporogenes, C.botulinum, C. caloritolerans, C. angenoti, C. ghoni, C.bifermentans, C. difficile, and C. sordellii while C. tetani,C. sticklandii, C. lituseburense, C. subterminale, C.putifaciens, C. propionicum, C. malenomenatum, C.limosum, C. lentoputrescens, C. tetanomorphum, C.coclearium, C. histolyticum, C. aminovalericum, and C.sporospheroides do not produce compounds that are converted to HPHPA.

The same article by Dr. Shaw indicates that 3,4-dihydroxyphenylpropionic acid (DHPPA) is a marker for beneficial bacteria in the gastrointestinal tract such as Lactobacilli, Bifidobacteria, and E. coli. The exception is one species of Clostridia orbiscindens that can convert the flavanoids luteolin and eriodictyol, that occur only in a relatively small food group that includes parsley, thyme, celery, and sweet red pepper to 3,4-dihydroxyphenylpropionic acid. The quantity of C. orbiscindens in the gastrointestinal tract is negligible (approximately 0.1% of the total bacteria) compared to the predominant flora of Lactobacilli, Bifidobacteria, and E. coli (7). DHPPA is an antioxidant that lowers cholesterol, reduces proinflammatory cytokines, and protects against pathogenic bacteria. 2,3-Dihydroxyphenypropionic acid, a different isomer has been claimed to be a metabolite of Pseudomonas species but the literature indicates that this compound is formed by the in vitro action of these species on quinoline, a component of coal tar, a substance missing from the diet of virtually all humans. 

http://integrativemedicineformentalhealth.com/articles/shaw_hphpa.html

Saturday, August 26, 2017

More Young People Are Dying of Colon Cancer - NYTimes.com

While rates of cancers tied to human papillomavirus, or HPV, have been rising in recent years, that virus causes cancers mainly of the cervix, back of the throat and anus, and scientists do not believe sexual behaviors or HPV are driving the increase in colon or rectal cancer (anal and rectal cancers are distinct).

Obesity, a diet high in red or processed meats and lack of physical activity are among the factors tied to increased risk, but new research is looking at other possible causes. One recent study found, for example, that prolonged use of antibiotics during adulthood was associated with a greater risk of developing precancerous polyps, possibly because antibiotics can alter the makeup of the gut microbiome.

https://mobile.nytimes.com/2017/08/22/well/live/more-young-people-are-dying-of-colon-cancer.html

Toxic metal hip replacements could cause Alzheimer's | Daily Mail Online

Doctors are being urged to check for signs of dementia or heart disease in hip implant patients.

There are concerns that the metal-on-metal devices are leaching toxic chemicals into the blood which cause serious health complications.

The Medicines and Healthcare products Regulatory Agency announced last month that patients would be called in for x-rays and blood tests to check for adverse reactions.

Now a spokesman for the watchdog said it was also keeping a 'weather eye' on a possible link to heart attacks and dementia.

Dr Neil McGuire, clinical director of medical devices at the MHRA, said he wanted to establish whether cobalt leached from the implants was causing adverse effects.
Patients with the 'metal on metal' hip implants will be advised to have X-rays and undergo blood tests due to fears of their toxicity

http://www.dailymail.co.uk/health/article-4682268/Fresh-warning-toxic-metal-hip-replacements.html

Saturday, August 19, 2017

Why You’re Not Losing Weight On Your Diet | Time.com

Another area that has some scientists excited is the question of how weight gain is linked to chemicals we are exposed to every day--things like the bisphenol A (BPA) found in linings of canned-food containers and cash-register receipts, the flame retardants in sofas and mattresses, the pesticide residues on our food and the phthalates found in plastics and cosmetics. What these chemicals have in common is their ability to mimic human hormones, and some scientists worry they may be wreaking havoc on the delicate endocrine system, driving fat storage.

"The old paradigm was that poor diet and lack of exercise are underpinning obesity, but now we understand that chemical exposures are an important third factor in the origin of the obesity epidemic," says Dr. Leonardo Trasande, an associate professor of pediatrics, environmental medicine and population health at New York University's School of Medicine. "Chemicals can disrupt hormones and metabolism, which can contribute to disease and disability."

Another frontier scientists are exploring is how the microbiome--the trillions of bacteria that live inside and on the surface of the human body--may be influencing how the body metabolizes certain foods. Dr. Eran Elinav and Eran Segal, researchers for the Personalized Nutrition Project at the Weizmann Institute of Science in Israel, believe the variation in diet success may lie in the way people's microbiomes react to different foods.

http://time.com/4793832/the-weight-loss-trap/

Wednesday, August 16, 2017

Japanese fungus spreading in UK hospitals - BBC News

What is Candida auris?

It belongs to a family of fungi or yeasts that live on the skin and inside the human body.

A more common "cousin" in this family is Candida albicans, which causes the yeast infection thrush.

Candida auris was first identified in 2009 in a patient from Japan.

Hospital outbreaks have since been reported in the United States, India, Pakistan, Venezuela, Colombia, Israel, Oman, South Africa and Spain, as well as the UK.


http://www.bbc.com/news/health-40934190

Wednesday, August 9, 2017

Medicare to cover supervised exercise for heart disease

Following a request from cardiologists, the CMS will now offer national Medicare coverage of supervised exercise therapy for treating peripheral artery disease

The agency said in a coverage decision released Thursday that research has shown supervised exercise therapy can help alleviate common symptoms of the cardiovascular disease, including pain and discomfort in a patient's legs.

Peripheral artery disease occurs when plaque buildup narrows the arteries outside the heart. It affects 12% to 20% of Americans age 60 and older, and the incidence of the disease increases considerably with age.

Without exercise, individuals with peripheral artery disease could see their condition worsen to the point they lose functional independence.

"Medicare beneficiaries, a significant portion of which have peripheral artery disease will benefit considerably from participating in supervised exercise therapy sessions," American Heart Association CEO Nancy Brown said in a statement. "Evidence shows this therapy can improve quality of life for patients and enhance clinical outcomes."

Supervised exercise is a non-invasive treatment option, which can alleviate leg pain during exercise and improve a patient's walking distance, according to the American Heart Association.



http://www.modernhealthcare.com/article/20170530/NEWS/170539995

Monday, August 7, 2017

Take the Generic, Patients Are Told. Until They Are Not. - NYTimes.com

Consumers have grown accustomed to being told by insurers — and middlemen known as pharmacy benefit managers — that they must give up their brand-name drugs in favor of cheaper generics. But some are finding the opposite is true, as pharmaceutical companies squeeze the last profits from products that are facing cheaper generic competition.

Out of public view, corporations are cutting deals that give consumers little choice but to buy brand-name drugs — and sometimes pay more at the pharmacy counter than they would for generics.

The practice is not easy to track, and has been going on sporadically for years. But several clues suggest it is becoming more common.


https://mobile.nytimes.com/2017/08/06/health/prescription-drugs-brand-name-generic.html